WebFeb 19, 2003 · Unlike heparin, this agent can neutralize clot-bound thrombin, does not require a cofactor, is not inactivated by circulating inhibitors, and does not bind to plasma proteins. 1,26 Furthermore, in contrast to the platelet-activating effect of heparin, bivalirudin may inhibit thrombin-mediated platelet activation. 27 Prior to our trial, clinical ... WebSep 16, 2013 · In a subgroup analysis of the ACUITY trial, the advantage of reduction of major bleeding seen with bivalirudin monotherapy over heparin plus GP IIb/IIIa inhibitors (eptifibatide 60%) was no longer significant when radial access was used (4.2% versus 2.2%, P=0.19). 44 In a single-center, prospective, registry study performed in the UK, 45 ...
Bivalirudin versus heparin in percutaneous coronary intervention-a ...
WebFeb 24, 2015 · While the data show that bivalirudin decreases bleeding when compared to heparin and routine GPI, the latter anticoagulation strategy is no longer utilized in most PCI cases. There was significant heterogeneity in the results based upon the concomitant use of GPI in the heparin arm. WebNov 8, 2024 · The largest randomized trial directly comparing bivalirudin with a high-dose infusion for two to four hours after treatment against unfractionated heparin without the routine use of glycoprotein IIb/IIIa inhibitors in patients with STEMI undergoing PCI strongly favored bivalirudin. smart and final colorado springs
Bivalirudin - StatPearls - NCBI Bookshelf
WebSep 21, 2024 · Bivalirudin specifically inhibits thrombin by binding both to the catalytic site and the anion-binding exosite on thrombin within thrombi and the circulation. This action … WebOf these, 1240 were treated with bivalirudin and 3496 with heparin according to the periprocedural anticoagulation strategies of PCI. The primary outcome was 12-month net adverse clinical events (NACE) defined as a composite of cardiac death, myocardial infarction, stroke, revascularization, or any bleeding. WebDec 8, 2024 · Argatroban and bivalirudin are parenteral direct thrombin inhibitors (DTIs) that have been used successfully in patients with VADs and on ECMO. Increasingly, ... Unlike heparin, bivalirudin can inhibit clot-bound thrombin. This drug can be monitored using PTT, titrating 1.5 to 2 times the normal value, although the response is not linear … hill builders inc