WebASH. Introduction : Daratumumab (DARA) is a novel human CD-38-targeting monoclonal antibody in clinical development for multiple myeloma (MM). In two clinical studies … WebNov 15, 2024 · Background: Daratumumab (Dara) combination therapy is approved in transplant ineligible newly diagnosed multiple myeloma (MM), and ongoing trials evaluating Dara in transplant eligible newly diagnosed MM may result in increased first-line (1L) use. Because Dara combinations are also approved in relapsed/refractory MM, patients may …
Updated Results from the Phase 2 Centaurus Study of …
WebEfficacy of daratumumab and hyaluronidase-fihji (monotherapy) was evaluated in COLUMBA (NCT03277105), an open-label non-inferiority trial randomizing 263 patients … WebAug 29, 2024 · From its introduction as monotherapy for multiple myeloma to its increasing utilization as a combination agent for relapsed or refractory multiple myeloma, daratumumab continues to be a major tool in the hematologist’s treatment armamentarium (See original Daratumumab Spotlight).Its indications in multiple myeloma include use as a single … iphone to usb adapter walmart
Updated Results from the Phase 2 Centaurus Study of Daratumumab (DARA ...
WebJan 6, 2016 · Daratumumab is a first-in-class, human IgG1 monoclonal antibody that binds CD38-expressing malignant cells with high affinity … WebNov 13, 2024 · Daratumumab (DARA) is a human IgGk monoclonal antibody targeting CD38 with a direct on-tumor and immunomodulatory mechanism of action that is approved for newly diagnosed and relapsed/refractory multiple myeloma (MM). ... DARA monotherapy demonstrated an encouraging response rate (ORR: 25%) in pts with R/R … WebNov 15, 2013 · The purpose of this study is to evaluate the efficacy and safety of 2 daratumumab treatment regimens in participants with multiple myeloma who have received at least 3 prior lines of therapy (including a proteasome inhibitor [PI] and immunomodulatory drug [IMiD]) or are double refractory to a PI and an IMiD. Detailed Description: iphone to usb drive