WebDec 15, 2024 · TRITON2 (NCT02952534) is an ongoing, international, open-label, phase II study evaluating rucaparib in patients with mCRPC associated with DDR deficiency. Men … WebJun 30, 2024 · The FDA granted accelerated approval to rucaparib for men with deleterious BRCA1/2 mutations based on the phase 2 TRITON2 study. 8 Eligible patients had been previously treated with androgen receptor-signaling inhibitors (ARSIs), prior taxane-based chemotherapy, and had a mutation in at least one gene from a larger HRR gene panel.
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WebSep 1, 2024 · In the TRITON2 study, 2 for example, it was observed that patients with BRCA1 mutations had more frequent co-alterations in TP53 (62%) and PTEN (69%) compared with those who had BRCA2 mutations ( TP53 alterations in 42% and … WebNov 2, 2016 · TRITON2: A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer Associated With Homologous … toddler boy green shirt
A Study of Rucaparib in Patients With Metastatic …
WebHi! I'm QualityVote, please vote on this comment to indicate whether you think the above artwork fits this community. If this post fits the purpose of r/wildart please UPVOTE THIS COMMENT - for guidance our rules are here. If this post does not fit the subreddit, please DOWNVOTE THIS COMMENT. If this post breaks the rules, please REPORT THE POST. … WebDec 15, 2024 · TRITON2 (NCT02952534) is an ongoing, international, open-label, phase II study evaluating rucaparib in patients with mCRPC associated with DDR deficiency. Men aged ≥18 years with histologically or cytologically confirmed mCRPC, Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, and adequate organ function were … WebJun 1, 2024 · The TRITON2 study is investigating the PARP inhibitor rucaparib in patients with mCRPC associated with alterations in 15 DDR genes. Here, we report an ad hoc … pentecost cake ideas